Removal of the pyrrolidine group by dehydrogenation of a 4-pyrrolidin-2-yl-tetrahydroisoquinoline

DOI: 10.1002/ardp.19923251011

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Archiv der Pharmazie p. 679 - 683 (1992)

Update date:2022-08-05

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Authors:

Mahboobi

Seidl Seidl

Eibler Eibler

Wiegrebe

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Article abstract of DOI:10.1002/ardp.19923251011

Dehydrogenation of 6,7-dimethoxy-1-methyl-4-(N-methyl-pyrrolidin-2-yl)-3,4-dihydroisoquin oline (9) by Pd/C in tetraline leads to dehydrogenated products, rearrangement, and elimination of the pyrrolidine group mainly as N-methylpyrrolidine (Scheme 3).

Full text of DOI:10.1002/ardp.19923251011

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