Removal of the pyrrolidine group by dehydrogenation of a 4-pyrrolidin-2-yl-tetrahydroisoquinoline

Article abstract of DOI:10.1002/ardp.19923251011

Dehydrogenation of 6,7-dimethoxy-1-methyl-4-(N-methyl-pyrrolidin-2-yl)-3,4-dihydroisoquin oline (9) by Pd/C in tetraline leads to dehydrogenated products, rearrangement, and elimination of the pyrrolidine group mainly as N-methylpyrrolidine (Scheme 3).