Chiral γ and δ Hydroxysulfones via Lipase Catalyzed Resolutions - Synthesis of (R)(+)-4-Hexanolide and (2R,5S)-2-Methyl-5-Hexanolide Using Intramolecular Acylation

Article abstract of DOI:10.1016/S0040-4020(01)81988-8

Lipase PS-30 (Amano) was found to be an effective catalyst for enantioselective transesterification of a number of racemic γ and δ hydroxysulfones with isopropenyl acetate in ether.The intramolecular acylation of the ethyl carbonate derivatives obtained f