A nitrile approach to the synthesis of the side chain of vitamin D metabolites and analogues

DOI: 10.1016/S0040-4039(00)61019-5

Source and publish data:

Tetrahedron Letters p. 6683 - 6686 (1992)

Update date:2022-08-03

Topics:

Authors:

Fall Fall

Torneiro

Castedo Castedo

Mourino Mourino

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)61019-5

An efficient new method for the construction of vitamin D hydroxylated side chains is described which is based on the alkylation and opening of epoxides by the α-anions derived from nitriles 6 and 7.

Full text of DOI:10.1016/S0040-4039(00)61019-5

Products guided by the article

Product name:(1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methyl-6-((triethylsilyl)oxy)heptan-2-yl)octahydro-1H-inden-4-ol

Cas No:145223-33-2

R&D Labs maybe for 145223-33-2

SJZ Chenghui Chemical Co., Ltd.

Contact:86-311-87713916

Address:no.368 youyi north avenue
Acros Pharmatech Limited

website:http://www.acrospharmatech.com

Contact:+1-3234804688

Address:Flat/RM 1502,Easey Commercial building 253-261 Hennessy Road,Wanchai，HongKong
Xiamen Huasing Chemicals Co.Ltd.

Contact:0086-592-6228397

Address:NO.24, Xinglin North 2nd Road,Jimei district
henan victory industry co.ltd

Contact:86-371-63655023

Address:No.85,jinshui road,zhengzhou,China
Shanghai Coupling Pharmaceutical R&D Co., Ltd.(expird)

Contact:+86 021 50106671

Address:403 Room No.4 Buiding, No. 526 Ruiqing Road, Shanghai Zhangjiang Hi-Tech Park

Relevant to this article

B-C bond cleavage of BAr_F anion upon oxidation of rhodium(I) with AgBAr_F. Phosphinite rhodium(I), rhodium(II), and rhodium(III) pincer complexes

Doi:10.1021/om800034t
(2008)
Asymmetric hydroformylation of conjugated dienes catalyzed by chiral phosphine-phosphite-Rh(I) complex

Doi:10.1016/S0040-4020(97)00471-7
(1997)
Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

Doi:10.1016/j.bmcl.2008.02.027
(2008)
Improved syntheses and applicability of different DOTA building blocks for multiply derivatized scaffolds

Doi:10.1016/j.bmc.2007.11.044
(2008)
Synthesis of RHPS4 via an anionic ring closing cascade

Doi:10.1016/j.tetlet.2008.02.074
(2008)
The activation of S_NAr reactions by the superstrong electron-withdrawing substituent CF3S(O)=NSO2CF3

Doi:10.1016/0022-1139(93)02959-I
(1994)

Article Doi