Journal of Medicinal Chemistry p. 4866 - 4874 (1992)
Update date:2022-08-05
Topics:
Suzuki, Fumio
Kuroda, Takeshi
Kawakita, Takashi
Manabe, Haruhiko
Kitamura, Shigeto
et al.
In order to develop new oral bronchodilators, a series of novel imidazo<4,5-c><1,8>naphthyridin-4(5H)-ones 5 were designed and synthesized.Some of these new heterocycles exhibited more potent bronchodilator activity in vitro and in vivo than theophylline.
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