New Bronchodilators. 3. Imidazonaphthyridin-4(5H)-ones

DOI: 10.1021/jm00104a013

Source and publish data:

Journal of Medicinal Chemistry p. 4866 - 4874 (1992)

Update date:2022-08-05

Topics:

Authors:

Suzuki, Fumio

Kuroda, Takeshi

Kawakita, Takashi

Manabe, Haruhiko

Kitamura, Shigeto

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00104a013

In order to develop new oral bronchodilators, a series of novel imidazo<4,5-c><1,8>naphthyridin-4(5H)-ones 5 were designed and synthesized.Some of these new heterocycles exhibited more potent bronchodilator activity in vitro and in vivo than theophylline.

Full text of DOI:10.1021/jm00104a013

Products guided by the article

Product name:1-<4-(ethoxycarbonyl)phenyl>-4-hydroxy-3-nitro-1,8-naphthyridin-2(1H)-one

Cas No:145255-87-4

R&D Labs maybe for 145255-87-4

Nanjing Fubang Chemical Co.,Ltd

Contact:+86-25-83179199

Address:5F,Tianzheng international plaza,No399 Zhongyang Road ,Nanjing China
Hubei Vanz Pharm Co.,Ltd

website:http://www.vanzpharm.com/en/index.html

Contact:86-27-84492310

Address:FANHU INDUSTRY PARK
Allicon Pharmaceuticals,Inc.

Contact:+86-519-86339586，13584329896

Address:Changzhou Scientific and Education Park
lianyungang jinkang pharmaceutical technology co., ltd.

Contact:008651885445517

Address:Jinshan industrial park, Ganyu county, Lianyungang, Jiangsu Province, 222115, China
Okeanos Tech.Co.,LTD

Contact:+86-10-62651721

Address:29 Yongxing Road, Daxing District,Beijing China

Relevant to this article

Synthesis of five-and six-membered 1,3,3-trimethyl-2-(trimethylsilyl) cycloalkenes: A novel preparation of alkyl/alkenyl/aryl 2,5,5-trimethyl-1- cyclopentenyl ketones

Doi:10.2298/JSC120501015A
(2013)
PhI(OAc)₂/I₂-mediated [3+2] reaction of [60]fullerene with amides for the preparation of fullerooxazoles

Doi:10.1016/j.tetlet.2013.09.002
(2013)
Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors

Doi:10.1021/acs.jmedchem.6b00697
(2016)
Design, synthesis and evaluation of some N-methylenebenzenamine derivatives as selective acetylcholinesterase (AChE) inhibitor and antioxidant to enhance learning and memory

Doi:10.1016/j.bmc.2017.01.010
(2017)
An efficient route to chiral N-heterocycles bearing a C-F stereogenic center via asymmetric hydrogenation of fluorinated isoquinolines

Doi:10.1039/c3cc45341c
(2013)
Synthesis of chiral seven-membered β-substituted lactams: Via Rh-catalyzed asymmetric hydrogenation

Doi:10.1039/c8ob02231c
(2018)

Article Doi