Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction

Article abstract of DOI:10.1021/jm00053a003

The protein kinase inhibitor staurosporine has been used to design a series of selective bisindolylmaleimide inhibitors of protein kinase C (PKC). Guided by molecular graphics, conformational restriction of the cationic side chain has led to ATP competiti