Benzolactam growth hormone secretagogues: Replacement of the C-3 amide bond in L-692,429

Article abstract of DOI:10.1016/S0960-894X(96)00566-5

The synthesis and structure-activity relationships of various C-3 amide bond modifications in the novel nonpeptidyl growth hormone secretagogue L-692,429 are described. Several C-3 amide surrogates were prepared and the urea moiety was found to exhibit growth hormone releasing activity similar to that observed with L-692,429.