Synthesis of 2-isoxazoline and α-hydroxy ketomethylene dipeptide isosteres

Article abstract of DOI:10.1016/0968-0896(95)00174-3

We have developed a simple and stereoselective method for synthesizing novel dipeptide isosteres using nitrile oxide cycloaddition as a key reaction. Employing this method, we have prepared efficiently various peptidomimetics containing 2-isoxazolines and