Synthesis of 2-isoxazoline and α-hydroxy ketomethylene dipeptide isosteres

DOI: 10.1016/0968-0896(95)00174-3

Source and publish data:

Bioorganic and Medicinal Chemistry p. 209 - 225 (1996)

Update date:2022-08-03

Topics:

Authors:

Chung, Yong Jun

Ryu, Eun Jung

Keum, Gyochang

Kim, Byeang Hyean

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Article abstract of DOI:10.1016/0968-0896(95)00174-3

We have developed a simple and stereoselective method for synthesizing novel dipeptide isosteres using nitrile oxide cycloaddition as a key reaction. Employing this method, we have prepared efficiently various peptidomimetics containing 2-isoxazolines and

Full text of DOI:10.1016/0968-0896(95)00174-3

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Product name:3-<(4R)-3-carboxybenzoxy-2,2-dimethyl-4-oxazolidinyl>-5-<(2R)-(bornane-10,2-sultamyl)-N-carbonyl>-(5R)-Δ²-isoxazoline

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