A General Preparation of Highly Functionalized Zinc and Copper Organometallics at the α-Position to an Oxygen

Article abstract of DOI:10.1021/jo00303a007

α-Bromoalkyl acetates 2, which are readily prepared by the addition of acetyl bromide to aldehydes, insert zinc under mild conditions affording, after the addition of CuCN*2LiCl, polyfunctional α-acetoxy copper reagents of type 1.Their reactivity toward various organic electrophiles is described.