Thiolysis of oxazolines: A new, selective method for the direct conversion of peptide oxazolines into thiazolines

DOI: 10.1016/0040-4039(95)01322-9

Source and publish data:

Tetrahedron Letters p. 6395 - 6398 (1995)

Update date:2022-08-04

Topics: Thiazoline Selective Reaction Bond Cleavage Heterocycle Thiolysis Oxazoline Direct Conversion

Authors:

Wipf, Peter

Miller, Chris P.

Venkatraman, Srikanth

Fritch, Paul C.

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Article abstract of DOI:10.1016/0040-4039(95)01322-9

A direct oxazoline→thiazoline conversion can be realized by thiolysis of oxazolines with H₂S in methanol/triethylamine, followed by cyclodehydration with Burgess reagent. This protocol is high-yielding, chemoselective, and essentially free of r

Full text of DOI:10.1016/0040-4039(95)01322-9

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