1,3,4-oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: In vitro inhibition of cyclooxygenase and 5-lipoxygenase activities

DOI: 10.1021/jm00065a002

Source and publish data:

Journal of Medicinal Chemistry p. 1802 - 1810 (1993)

Update date:2022-08-04

Topics:

Authors:

Boschelli

Connor Connor

Bornemeier

Dyer Dyer

Kennedy Kennedy

Kuipers Kuipers

Okonkwo Okonkwo

Schrier Schrier

Wright Wright

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Article abstract of DOI:10.1021/jm00065a002

N-Arylanthranilic acids, known generically as the fenamates, are nonsteroidal antiinflammatory drugs (NSAIDs) that block the metabolism of arachidonic acid by the enzyme cyclooxygenase (CO). Substitution of the carboxylic acid functionality of several fen

Full text of DOI:10.1021/jm00065a002

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