Journal of the Chemical Society. Perkin transactions I p. 3129 - 3134 (1992)
Update date:2022-07-29
Topics:
Iddon, Brian
Kutschy, Peter
Robinson, Andrew G.
Suschitzky, Hans
Kramer, Walter
Neugebauer, Franz A.
A new synthesis of the selective anthelmintic agent triclabendazole 7 from the readily available 5,6-dichloro-2H-benzimidazole-2-spirocyclohexane 2 by simple steps is described.Analogous benzimidazoles difficult to prepare by conventional methods are similarly obtained.Triclabendazole can exist as a low-melting metastable solid (m.p. 85-90 deg C) convertible by heating or recrystallisation from ethanol into its stable form (m.p. 176-178 deg C).
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