The preparation of intermediates for the synthesis of 1D-myo-inositol 1,4,5-triphosphate, a second messenger for signal transduction in cells

DOI: 10.1016/0008-6215(92)85035-X

Source and publish data:

Carbohydrate Research p. 1 - 22 (1992)

Update date:2022-08-04

Topics: Column chromatography NMR spectroscopy Synthetic route Recrystallization Intermediates Hydrolysis Mass spectrometry (MS) Protecting groups High-performance liquid chromatography (HPLC) Deprotection TLC (thin-layer chromatography) Anhydrous conditions Signal Transduction Phosphorylation Reaction Optimization Chiral synthesis Yield calculation Phosphoramidite chemistry

Authors:

Desai, Trupti

Gigg, Jill

Gigg, Roy

Payne, Sheila

Penades, Soledad

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Article abstract of DOI:10.1016/0008-6215(92)85035-X

Racemic 1,2,4-tri-O-benzyl-5,6-O-isopropylidene-myo-inositol was prepared by a new route involving crotyl (but-2-enyl) ethers and converted into (-)-ω-camphanates to give the pure crystalline 1L-diastereoisomer and the chirally impure, syrupy 1D-diastereo

Full text of DOI:10.1016/0008-6215(92)85035-X

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Product name:(+/-)-1-O-benzyl-4-O-p-methoxybenzyl-myo-inositol

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