Podophyllotoxin aza-analogue, a novel DNA topoisomerase II inhibitor

DOI: 10.1248/cpb.48.486

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 486 - 489 (2000)

Update date:2022-08-04

Topics:

Authors:

Iida, Akira

Kano, Masahiro

Kubota, Yoshiro

Koga, Kenji

Tomioka, Kiyoshi

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Article abstract of DOI:10.1248/cpb.48.486

The pendant E-ring moiety of the podophyllotoxin aza-analogue 1 that is a potent inhibitor of microtubule assembly was modified in order to acquire inhibitory activity of DNA topoisomerase II. The monophenolic analogue 2 did not exhibit human topoisomeras

Full text of DOI:10.1248/cpb.48.486

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Product name:2-aza-4'-demethyldeoxypodophyllotoxin

Cas No:146308-77-2

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