Chemical and Pharmaceutical Bulletin p. 486 - 489 (2000)
Update date:2022-08-04
Topics:
Iida, Akira
Kano, Masahiro
Kubota, Yoshiro
Koga, Kenji
Tomioka, Kiyoshi
The pendant E-ring moiety of the podophyllotoxin aza-analogue 1 that is a potent inhibitor of microtubule assembly was modified in order to acquire inhibitory activity of DNA topoisomerase II. The monophenolic analogue 2 did not exhibit human topoisomeras
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