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Inhibition of matrix metalloproteinases: An examination of the S1' pocket

DOI: 10.1016/S0960-894X(96)00602-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 193 - 198 (1997)

Update date:2022-08-03

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Authors:

Miller, AndrewMiller, Andrew

Askew, MarionAskew, Marion

Beckett, R. PaulBeckett, R. Paul

Bellamy, Claire L.Bellamy, Claire L.

Bone, Elisabeth A.Bone, Elisabeth A.

Coates, Rachael E.Coates, Rachael E.

Davidson, Alan H.Davidson, Alan H.

Drummond, Alan H.Drummond, Alan H.

Huxley, PhilipHuxley, Philip

Martin, Fionna M.Martin, Fionna M.

Saroglou, LydiaSaroglou, Lydia

Thompson, Alison J.Thompson, Alison J.

Van Dijk, Sonja E.Van Dijk, Sonja E.

Whittaker, MarkWhittaker, Mark

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Article abstract of DOI:10.1016/S0960-894X(96)00602-6

Peptidomimetic carboxylate- and hydroxamate-based inhibitors of matrix metalloproteinases containing extended P1' groups have been prepared. Potent inhibition and good selectivity for MMP-2 has been observed for the compounds produced.

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Full text of DOI:10.1016/S0960-894X(96)00602-6

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Product name:(S)-4-benzyl-3-tetradecanoyloxazolidin-2-one

Cas No:145816-90-6

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