Development of selective tight-binding inhibitors of leukotriene A4 hydrolase

Article abstract of DOI:10.1021/jm00054a004

Leukotriene A₄ hydrolase is a zinc-containing enzyme which exhibits both epoxide hydrolase and aminopeptidase activities. Since the enzyme product leukotriene B₄ is an inflammatory mediator, it is of interest to develop selective inh