Synthesis of 2,2'-Anhydro-1-(3'-deoxy-3'-bromo-β-D-arabinofuranosyl)thymine and Its Derivatives from 5'-O-Trityl-2',3'-thymidinene

Article abstract of DOI:10.1246/cl.1992.2149

Reaction of 5'-O-trityl-2',3'-thymidinene with hypobromous acid gave 2,2'-anhydro-1-(3'-deoxy-3'-bromo-5'-O-trityl-β-D-arabinofuranosyl)-(5R,6R)-trans-5-bromo-6-hydroxy-5,6-dihydrothymine (3) and its (5S,6S) trans analogue (4).These were transformed into