Oxidation and Alkylation of Spectinomycin Derivatives: Synthesis of Trospectomycin from Spectinomycin

DOI: 10.1021/jo00055a021

Source and publish data:

Journal of Organic Chemistry p. 678 - 682 (1993)

Update date:2022-09-26

Topics:

Authors:

Herrinton, Paul M.

Klotz, Karen L.

Hartley, William M.

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Article abstract of DOI:10.1021/jo00055a021

Trospectomycin can be prepared in five steps from spectinomycin.The overall yield of the process is 13.3 percent.The synthesis involves a new oxidation of silyl enol ether 4 to enone 5 by use of an alkyl hydroperoxide.This reaction is mild and very selcti

Full text of DOI:10.1021/jo00055a021

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