Tetrahedron p. 3011 - 3017 (2014)
Update date:2022-08-04
Topics:
Yarmolchuk, Vladimir S.
Mykhalchuk, Vladimir L.
Mykhailiuk, Pavel K.
(R-)- and (S-)-3-fluoro-3-aminomethylpyrrolidines were synthesized from methyl α-fluoroacrylate in eight steps. α-Phenylethylamine was used as a chiral auxiliary to separate the racemic mixture. The overall synthesis yield was 31%.
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Doi:10.1016/0040-4039(93)88038-K
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