A Convenient Stereoselective Synthesis of a (-)-Vertinolide Precursor

DOI: 10.1016/S0040-4039(00)74710-1

Source and publish data:

Tetrahedron Letters p. 8035 - 8038 (1992)

Update date:2022-08-04

Topics:

Authors:

Datta, Apurba

Datta, Dinah

Schmidt, Richard R.

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Article abstract of DOI:10.1016/S0040-4039(00)74710-1

A short practical method for the enantioselective synthesis of (-)-vertinolide precursor 2 is described.The readily available chiral β-alkoxy substituted acrylate 7 has been reacted with ethyl levulinate to form the tetronic acid nucleus 8, which in three subsequent steps was converted to the known precursor 2 in high overall yield.

Full text of DOI:10.1016/S0040-4039(00)74710-1

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