Preparation of Imidazolones from N-cyano-N'-methylcarboxyguanidines. An Unusual C-N-Bond Formation in the Hydrogenolysis of a Benzyl Ester in an Attempted Synthesis of an Inhibitor of Carboxypeptidase A

DOI: 10.1016/S0040-4020(01)80431-2

Source and publish data:

Tetrahedron p. 6885 - 6898 (1993)

Update date:2022-07-29

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Authors:

Garratt, Peter J.

Thorn, Simon N.

Wrigglesworth, Roger

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Article abstract of DOI:10.1016/S0040-4020(01)80431-2

Hydrogenolysis of the benzyl ester 5 gave the imidazolone 6 rather than the desired acid 1, and the related benzyl ester 11 also hydrogenolysed to the imidazolone 12.Examination of the hydrolysis of simpler guanidine derivatives with trifluoroacetic acid

Full text of DOI:10.1016/S0040-4020(01)80431-2

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