Preparation of Imidazolones from N-cyano-N'-methylcarboxyguanidines. An Unusual C-N-Bond Formation in the Hydrogenolysis of a Benzyl Ester in an Attempted Synthesis of an Inhibitor of Carboxypeptidase A

DOI: 10.1016/S0040-4020(01)80431-2

Source and publish data:

Tetrahedron p. 6885 - 6898 (1993)

Update date:2022-07-29

Topics:

Authors:

Garratt, Peter J.

Thorn, Simon N.

Wrigglesworth, Roger

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(01)80431-2

Hydrogenolysis of the benzyl ester 5 gave the imidazolone 6 rather than the desired acid 1, and the related benzyl ester 11 also hydrogenolysed to the imidazolone 12.Examination of the hydrolysis of simpler guanidine derivatives with trifluoroacetic acid

Full text of DOI:10.1016/S0040-4020(01)80431-2

Products guided by the article

Product name:N-cyano-N'-(S)-(1-benzyloxycarbonyl-2-phenylethyl)-O-phenylisourea

Cas No:146335-67-3

R&D Labs maybe for 146335-67-3

Suzhou CarbonWell Pharma-Tech Co., Ltd

Contact:Tel: + 86 (0)512-8898-1216; + 86-18606258602

Address:2358 Changan Road, Wujiang Scientific Innovation Park, Wujiang, Jiangsu Province, P. R. China 215200
Jiangxi Dongbang Pharmaceutical Co., Ltd.

Contact:+86-795-4433603, 4433388

Address:Fengxin Industrial Park, Fengxin County, Jiangxi Province, P.R.C
Suzhou SuKaiLu Chemical Technology Co., Ltd.

Contact:+86-512-62766020

Address:Floor 4, Building 1, Xinyi Pharmaceutical Valley Wisdom Industrial Park, 415 Changyang Street, Suzhou Industrial Park, Jiangsu Province
Hebei DaPeng Pharm & Chem Co., Ltd.

Contact:86-317-7298678,0576-88861898 88861908

Address:West Songmen Village, East Songmen Town, Wuqiao, Cangzhou, Hebei ,China
KangZhiYuan Pharmaceutical Company Limited

Contact:(Sabrina)86-20-85273232

Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China

Relevant to this article

INVESTIGATION OF THE ALKYLATION OF NITROAZOLES WITH α-HALOKETONES BY 13C, 15N, AND 14N NMR

Doi:10.1007/BF00961497
(1990)
Doi:10.1021/ja01233a024
(1944)
Sequential three-component reactions: Synthesis, regioselectivity and application of functionalized dihydropyridines (DHPs) for the creation of fused naphthyridines

Doi:10.1016/j.tetlet.2011.04.098
(2011)
Tandem ring opening/cyclization of vinylcyclopropanes: A facile synthesis of chiral bicyclic amidines

Doi:10.1002/anie.201100375
(2011)
Asymmetric epoxidation of α,β-unsaturated ketones via an amine-thiourea dual activation catalysis

Doi:10.1016/j.tetlet.2021.152941
(2021)
Copper(II) and Nickel(II) Complexes of N,N',N'',N'''-Tetrakis(2-aminoethyl)-1,4,7,11-tetra-azacyclotetradecane (taei), -1,4,8,12-tetra-azacyclopentadecane (taep), and -1,5,9,13-tetra-azacyclohexadecane (taeh). Crystal Structures of 4, and 4, and ....

Doi:10.1039/DT9900002763
(1990)

Article Doi