Synthesis and antibacterial activity evaluation of 2,6-bis(6-substituted-1, 2,4-triazolo[3,4-b][1,3,4]thiadiazol-3-yl)pyridine derivatives

Article abstract of DOI:10.1007/s00044-013-0790-2

The reaction of 5,5′-(pyridine-2,6-diyl)bis(4-amino-3-mercapto-1,2,4- triazole) with various carboxylic acid in phosphorus oxychloride yielded the corresponding 2,6-bis(6-substituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-3-yl) pyridine derivatives 6a-l. The structures of the newly synthesized compounds were confirmed by elemental analysis, ¹H NMR and ¹³C NMR spectral, mass spectral, and Infrared spectral studies. All the synthesized target compounds have been investigated for their in vitro antibacterial activity, and the preliminary results revealed that the compounds 6b and 6k exhibited very promising activity against Escherichia coli and Pseudomonas aeruginosa. Springer Science+Business Media 2013.