A facile synthesis of 2-phosphoryl-substituted 3-hydroxyindole derivatives

Article abstract of DOI:10.1055/s-1992-26357

A variety of 1-substituted 2-diphenylphosphinoyl-3-hydroxy-1H-indoles 5 a-d and 2-dimethoxyphosphoryl-3-hydroxy-1H-indoles 6a,c have been efficiently prepared by base-induced intramolecular cyclization of the appropriate Horner-Wittig and Wadsworth-Emmons reagents, 2-[(diphenylphosphinoyl)methylamino]-N,N-diethylbenzamides 3a-d and 2-[(dimethoxyphosphoryl)methylamino]-N,N-diethylbenzamides 4a,c, respectively.