E- OR Z-SELECTIVE WITTIG REACTIONS IN THE SYNTHESIS OF THE CARBACYCLIN ILOPROST

DOI: 10.1016/S0040-4039(00)74715-0

Source and publish data:

Tetrahedron Letters p. 8055 - 8056 (1992)

Update date:2022-08-05

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Authors:

Westermann, Juergen

Harre, Michael

Nickisch, Klaus

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Article abstract of DOI:10.1016/S0040-4039(00)74715-0

Wittig reaction of ketones 3 with 4-carboxybutyltriphenyl-phosphonium bromide generates the exocyclic 5,6 double bond of iloprost (1) in E/Z ratios between 35:65 and 90:10 depending on substituents and reaction conditions.

Full text of DOI:10.1016/S0040-4039(00)74715-0

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