Synthesis and Selective Cleavage of an Oligodeoxynucleotide Containing a Bridged Non-Chiral Internucleotide 3'-Phosphoramidate Linkage

DOI: 10.1016/S0040-4039(00)60176-4

Source and publish data:

Tetrahedron Letters p. 7319 - 7323 (1992)

Update date:2022-08-04

Topics:

Authors:

Mag, Matthias

Schmidt, Rainer

Engels, Joachim W.

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Article abstract of DOI:10.1016/S0040-4039(00)60176-4

A self complementary oligodeoxynucleotide dodecamer containing an achiral bridged 3'-phosphoramidate linkage 3'-NH-P-O-5' has been prepared using the solid phase phosphoramidate procedure.Cleavage of the P-N bond can be accomplished selectively by mild acidolysis.

Full text of DOI:10.1016/S0040-4039(00)60176-4

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