Synthesis and Pharmacological Evaluation of 1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as Ligands for a Novel Receptor with ?-like Neuromodulatory Activity

DOI: 10.1021/jm00069a013

Source and publish data:

Journal of Medicinal Chemistry p. 2542 - 2551 (1993)

Update date:2022-08-04

Topics:

Authors:

Wyrick, Steven D.

Booth, Raymond G.

Myers, Andrew M.

Owens, Constance E.

Kula, Nora S.

et al. et al.

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Article abstract of DOI:10.1021/jm00069a013

Certain novel 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes (1-phenyl-3-aminotetralins, PATs) produced stimulation (ca. 30percent above basal levels) of tyrosine hydroxylase (TH) activity at 0.1 μM concentrations in rodent brain tissue. This effect on T

Full text of DOI:10.1021/jm00069a013

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