Journal of Medicinal Chemistry p. 855 - 862 (1993)
Update date:2022-08-04
Topics:
Meltzer, P. C.
Liang, A. Y.
Brownell, A.-L.
Elmaleh, D. R.
Madras, B. K.
It is now accepted that (-)-cocaine binds to specific recognition sites associated with monoamine transporters in the mammalian brain. In this study, several analogs of 3β-phenyltropane-2β-carboxylic acid methyl ester were prepared and their potency for inhibiting the binding of <3H>-3β-(4-fluorophenyl)tropane-2β-carboxylic acid methyl ester to primate caudate-putamen was evaluated. The synthesis and binding affinity of 3β-(3,4-dichlorophenyl)tropane-2β-carboxylic acid methyl ester, one of the most potent cocaine congeners yet reported, is presented. The feasibility of synthesizing high-affinity ligands for cocaine recognition sites and their suitability as PET imaging ligands for cocaine receptors in vivo is demonstrated.
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Doi:10.1016/S0040-4039(00)61663-5
(1993)Doi:10.1021/ja01156a086
(1951)Doi:10.1021/jm00046a016
(1994)Doi:10.1021/jm020094i
(2002)Doi:10.1002/cjoc.201090059
(2010)Doi:10.1016/j.poly.2008.08.014
(2008)