Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones

DOI: 10.1016/j.bmc.2015.06.007

Source and publish data:

Bioorganic and Medicinal Chemistry p. 4522 - 4532 (2015)

Update date:2022-07-30

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Authors:

Lee, Chia-Chung

Liu, Fei-Lan

Chen, Chun-Liang

Chen, Tsung-Chih

Liu, Feng-Cheng

Ahmed Ali, Ahmed Atef

Chang, Deh-Ming

Huang, Hsu-Shan

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Article abstract of DOI:10.1016/j.bmc.2015.06.007

A series of novel 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione derivatives were synthesized and evaluated for their inhibitory effects on osteoclast activities by using TRAP-staining assay. Among the tested compounds, 3d and 3h ex

Full text of DOI:10.1016/j.bmc.2015.06.007

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