Synthesis and phosphorylating properties of hydroxyamino acid phosphoramidites

Article abstract of DOI:10.1055/s-1992-26355

The preparation of N-(benzyloxycarbonyl)-O-[(benzyloxy)(diisopropylamino)phosphino]serine [-threonine, -tyrosine and -hydroxyproline] benzyl esters using the versatile phosphitylating reagent benzyl N,N,N',N'-tetraisopropylphosphorodiamidite [benzyloxybis(diisopropylamino)phosphine] is described. The application of the benzyl (hydroxyamino acid) phosphoramidites is illustrated in the synthesis of several phosphate diesters.