
Synthesis p. 1269 - 1272 (1992)
Update date:2022-07-29
Topics:
Dreef-Tromp
Lefeber
Van Der Marel
Van Boom
The preparation of N-(benzyloxycarbonyl)-O-[(benzyloxy)(diisopropylamino)phosphino]serine [-threonine, -tyrosine and -hydroxyproline] benzyl esters using the versatile phosphitylating reagent benzyl N,N,N',N'-tetraisopropylphosphorodiamidite [benzyloxybis(diisopropylamino)phosphine] is described. The application of the benzyl (hydroxyamino acid) phosphoramidites is illustrated in the synthesis of several phosphate diesters.
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(1986)