Calcium antagonism and structure-affinity relationships of terfenadine, a histamine H1 antagonist and some related compounds

Article abstract of DOI:10.1111/j.2042-7158.1993.tb03681.x

Calcium channel affinity of terfenadine and its optical isomers was determined by the displacement of [³H]nitrendipine on rat cerebral cortex membranes. Terfenadine showed a pK(d) of 6.36 ± 0.03 whereas its R(+)-isomer (VUF4567) had a pK(d) val