An efficient synthesis and acylation of α-amino-β-keto-esters: Versatile intermediates in the synthesis of peptide mimetics

Article abstract of DOI:10.1016/S0040-4039(00)60549-X

A flexible and high yield synthesis of α-amino-β-keto esters has been developed via acylation of the ketimine derivatives of α-amino esters. These α-amino-β-keto-esters were acylated with chiral amino acid derivatives in 36-95% yields.