Inhibitory effects of (4-alkoxy-2, 3, 6-trimethylphenyl) glycopyranosides on histamine release induced by antigen-antibody reaction

Article abstract of DOI:10.1248/cpb.42.1002

The inhibitory effects of newely synthesized 4-alkoxy-2, 3, 6-trimethylphenyl D-glycopyranosides on histamine release induced by antigen-antibody reaction were examined. Among the compounds tested, 4-hexoxy-2, 3, 6-trimethylphenyl α-D-mannopyranoside exhibited the strongest inhibitory effect. Furthermore, 4-hexoxy-2, 3, 6-trimethylphenyl α-D-glucopyranoside and α-D-galactopyranoside markedly inhibited antigen-induced histamine release, and their activities were more potent than those of the corresponding β-anomers. These results suggest that these compounds may possess excellent anti-allergic activities.

Full text of DOI:10.1248/cpb.42.1002

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