Synthesis and anti lipid-peroxidation activity of hydroquinone monoalkyl ethers

DOI: 10.1248/cpb.42.576

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 576 - 579 (1994)

Update date:2022-08-06

Topics:

Authors:

Nihro Nihro

Furukawa

Sogawa Sogawa

Wang Wang

Miyataka

Matsumoto

Miki Miki

Satoh Satoh

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.576

A series of hydroquinone monoalkyl ethers was synthesized and evaluated for anti lipid-peroxidation activity in rat liver microsomes. 4-Hexyloxy- 2,3,6-trimethylphenol (9), having a low redox potential, as well as ascorbic acid exhibited the strongest anti lipid-peroxidation activity (IC₅₀ = 4.2 x 10^-7 M). Structure-activity relationship studies demonstrated that the inhibitory effect of hydroquinone monoalkyl ethers on lipid peroxidation was increased by the acquisition of an optimum hydrophobicity and decreased by an insufficient or excessive hydrophobicity.

Full text of DOI:10.1248/cpb.42.576

NII-Electronic Library Service

Products guided by the article

Product name:Octyl-(4-hydroxy-2.3.5-trimethyl-phenyl)-aether

Cas No:148081-75-8

R&D Labs maybe for 148081-75-8

HuiFeiChem PharmaTech Co.Ltd

Contact:0510-85393305

Address:1619 Huishan Avenue, Huishan District, Wuxi,
Shanxi Tongji Pharmaceuticals Co., Ltd.

Contact:+86-359-3024784

Address:Xikuang South Road, Ruicheng County , Shanxi
Jiangsu Fengshan Group Co., Ltd.

Contact:86-25-86558671

Address:1903,Central International Mansion 105-6 North Zhongshan Road, Nanjing, China
Xi'an HO-SHINE Bio-Technology Co., Ltd

Contact:+86 (29) 8248-5435/18292020086

Address:No.6 Shiyuan Road Xian City Shaanxi Province, 710048 China
Chemsigma International Co.,Ltd.

website:http://www.chemsigma.com

Contact:86-025-58748998

Address:Rm.705, 15th Building,Rd.Xinke II

Relevant to this article

ELECTROPHILIC QUENCHING OF DIANIONS OF 4-<5'-SULFONYLMETHYLISOXAZOLYL>-1,4-DIHYDROPYRIDINES. A DIRECT ROUTE TO FUNCTIONALIZED HANTZSCH ESTERS

Doi:10.1016/S0040-4039(00)77500-9
(1993)
Tertiary Phosphine Adducts of t)4>. Crystal Structure of <2(μ-O2CBu^t)3(O2CBu^t)(PMe2Ph)2>

Doi:10.1039/DT9930000877
(1993)
Synthesis of (2S,3S)-2-amino-3-methylpent-4-ynoic Acid, a Precursor Amino Acid for the Preparation of Tritium- or Deuterium-Labelled Peptide in the Isoleucine Residue

Doi:10.1039/P19930000489
(1993)
Membrane-permeable Mn(III) complexes for molecular magnetic resonance imaging of intracellular targets

Doi:10.1021/jacs.5b13337
(2016)
Doi:10.1007/BF00944293
()
Block synthesis of tetra- and hexasaccharides (β-D-glycero-D-manno- hepp-(1→4)-[α-L-rhap-(1→3)-β-D-glycero-D-manno-hepp- (1→4)]_n-α-L-rhap-OMe (n = 1 and 2)) corresponding to multiple repeat units of the glycan from the surface-layer glycoprotein from Bacillus thermoaerophilus

Doi:10.1021/jo801414c
(2008)

Article Doi