Synthesis and anti lipid-peroxidation activity of hydroquinone monoalkyl ethers

DOI: 10.1248/cpb.42.576

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 576 - 579 (1994)

Update date:2022-08-06

Topics:

Authors:

Nihro Nihro

Furukawa

Sogawa Sogawa

Wang Wang

Miyataka

Matsumoto

Miki Miki

Satoh Satoh

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Article abstract of DOI:10.1248/cpb.42.576

A series of hydroquinone monoalkyl ethers was synthesized and evaluated for anti lipid-peroxidation activity in rat liver microsomes. 4-Hexyloxy- 2,3,6-trimethylphenol (9), having a low redox potential, as well as ascorbic acid exhibited the strongest anti lipid-peroxidation activity (IC₅₀ = 4.2 x 10^-7 M). Structure-activity relationship studies demonstrated that the inhibitory effect of hydroquinone monoalkyl ethers on lipid peroxidation was increased by the acquisition of an optimum hydrophobicity and decreased by an insufficient or excessive hydrophobicity.

Full text of DOI:10.1248/cpb.42.576

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