Chemoenzymatic carbon-carbon bond formation leading to non-carbohydrate derivative. Stereoselective synthesis of pentamycin C-11-C-16 fragment

Article abstract of DOI:10.1248/cpb.41.282

Chemoenzymatic formation of 8 from an aldehyde 5 and dihydroxyacetone phosphate 6 was achieved by the use of fructose 1,6-diphosphate aldolase as a catalyst. Transformation of 8 to 20, corresponding to pentamycin C-11-C-16 fragment, was accomplished via 18a and 18b by chemical processes.