Total synthesis of (±)-deethyleburnamonine and vindeburnol (RU 24722) with the corresponding nitriles as starting material

Article abstract of DOI:10.3987/COM-99-8486

Cyclisation occurred during base treatment of cis-nitrile (5). The resulting new imine (6) was converted into the therapeutically important deethyleburnamonine (4). Total synthesis of vindeburnol (RU 24722) (3), another important drug, was achieved in one step starting from the trans- nitrile (9).