Bioorganic and Medicinal Chemistry p. 673 - 678 (1997)
Update date:2022-09-26
Topics:
Heitsch, Holger
Becker, Reinhard H.A.
Kleemann, Heinz-Werner
Wagner, Adalbert
The synthesis and the SAR study of imidazo[4,5-b]pyridine biphenyl sulfonylureas and -carbamates as highly potent AT1-seIective ANG II receptor antagonists are described. Several members of this new class of antagonists efficiently inhibited the ANG II-induced presser response in pithed rats after iv and intraduodenal (id) administration.
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