3N-Methylbiphenylsulfonylurea and -carbamate substituted imidazo[4,5-b]pyridines. Potent antagonists of the ANG II AT1 receptors

DOI: 10.1016/S0968-0896(97)00012-6

Source and publish data:

Bioorganic and Medicinal Chemistry p. 673 - 678 (1997)

Update date:2022-09-26

Topics:

Authors:

Heitsch, Holger

Becker, Reinhard H.A.

Kleemann, Heinz-Werner

Wagner, Adalbert

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0968-0896(97)00012-6

The synthesis and the SAR study of imidazo[4,5-b]pyridine biphenyl sulfonylureas and -carbamates as highly potent AT₁-seIective ANG II receptor antagonists are described. Several members of this new class of antagonists efficiently inhibited the ANG II-induced presser response in pithed rats after iv and intraduodenal (id) administration.

Full text of DOI:10.1016/S0968-0896(97)00012-6

Products guided by the article

Product name:4'-(2-Butyl-imidazo[4,5-b]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid amide

Cas No:148402-25-9

R&D Labs maybe for 148402-25-9

TLS PHARMACEUTICAL CO.,LTD

Contact:0833-5590788/5590338/5590055

Address:Victory in the town of Red Star Village,Mount Emei City,industrial concentration area storage processing logistics parkpark
Jintan City Mego Chemical Co., Ltd

Contact:+86-0519-82814387

Address:23# Dengguan Town, Jintan, Jiangsu Province, China
Clearsynth Labs Limited

Contact:+91 - 22 - 26355700

Address:17, Lotus Business Park, Andheri West
Wuhan Fortuna Chemical Co.,Ltd

website:http://www.fortunachem.com

Contact:86-27-59207850

Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China
Tianjin Hedong Red Cliff Chemical Reagent Factory

Contact:+86-022-84780548

Address:Li Ming Zhuang Gong Ye Yuan,Dongli District,Tianjin,China

Relevant to this article

Reductive cyclizations of nitroarenes to hydroxamic acids by visible light photoredox catalysis

Doi:10.1055/s-0033-1338419
(2013)
Modified steroid hormones. XLI. Rearrangement of 3 beta-acetoxy-4a alpha-hydroxy-5 beta-methyl-A-homo-B-nor steroids into normal steroids of the 6-methylene-5 beta-H series.

Doi:10.1016/S0040-4020(01)96936-4
(1965)
Enantiocontrolled Synthesis of Optically Pure 5-Trimethylsilyl- and 5-Tributylstannyl-cyclohex-2-enones

Doi:10.1039/c39930000788
(1993)
SO₃H-functionalized metal organic frameworks: An efficient heterogeneous catalyst for the synthesis of quinoxaline and derivatives

Doi:10.1039/c6ra02575g
(2016)
A general route to α,α-difluoroketones

Doi:10.1016/S0040-4039(00)73671-9
(1993)
<2,3>-Sigmatropic Rearrangement of β-Phenylsulfonyl Propargylic Sulfenates as a Method for Preparing 1,4-Bis(phenylsulfonyl)-1,3-butadienes

Doi:10.1021/jo00072a019
(1993)

Article Doi