3N-Methylbiphenylsulfonylurea and -carbamate substituted imidazo[4,5-b]pyridines. Potent antagonists of the ANG II AT1 receptors

DOI: 10.1016/S0968-0896(97)00012-6

Source and publish data:

Bioorganic and Medicinal Chemistry p. 673 - 678 (1997)

Update date:2022-09-26

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Authors:

Heitsch, Holger

Becker, Reinhard H.A.

Kleemann, Heinz-Werner

Wagner, Adalbert

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Article abstract of DOI:10.1016/S0968-0896(97)00012-6

The synthesis and the SAR study of imidazo[4,5-b]pyridine biphenyl sulfonylureas and -carbamates as highly potent AT₁-seIective ANG II receptor antagonists are described. Several members of this new class of antagonists efficiently inhibited the ANG II-induced presser response in pithed rats after iv and intraduodenal (id) administration.

Full text of DOI:10.1016/S0968-0896(97)00012-6

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