Nonsymmetrical bipiperidyls as inhibitors of vesicular acetylcholine storage

Article abstract of DOI:10.1021/jm00060a005

Introduction of a nitrogen atom into the cyclohexane ring of 2-(4- phenylpiperidinyl)cyclohexanol (vesamicol, AH5183) yielded two positional isomers, 5-azavesamicol (5, prezamicol) and 4-azavesamicol (6, trozamicol). As inhibitors of vesicular acetylcholi