Synthesis of cyclophosphamide analogs from aminotrideoxy sugars

Article abstract of DOI:10.1016/0008-6215(93)84195-C

Cyclophosphamide 1a is a highly effective and extensively used agent for the treatment of human cancers. The metabolism, pharmacokinetics, and mechanism of action of 1a are frequently reviewed. By analogy with well known strategy in the design of potentia