A facile chemoenzymatic route to enantiomerically pure 4,5-disubstituted-2-hexenoae derivatives

DOI: 10.1248/cpb.39.3094

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 3094 - 3096 (1991)

Update date:2022-08-04

Topics: Synthesis Enantiomerically pure Derivatives Enantiomeric purity Facile Route Chemoenzymatic

Authors:

Akita Akita

Umezawa Umezawa

Takano Takano

Matsukura

Oishi Oishi

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Article abstract of DOI:10.1248/cpb.39.3094

The reaction of 4,5-epoxy-2-hexenoate 2 and various nucleophiles in the presence of BF₃.Et₂O predominantly gave the (4,5)-5-hydroxy-4-substituted compounds. Among them, (±)-(4,5)-anti-5-hydroxy-4-thiophenoxy ester 17 was enantioselec

Full text of DOI:10.1248/cpb.39.3094

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Product name:(+/-) methyl (2,5)-anti-5-hydroxy-2-(2',4',5'-trimethoxyphenyl)-(3E)-hexenoate

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