European Journal of Medicinal Chemistry p. 3 - 12 (1993)
Update date:2022-09-26
Topics:
Ho, W
Hageman, W E
Stanley, K G
Gallant, W R
Cherry, D A
et al.
A series of 6-hydroxy-7-thioether and 6-thioether-7-hydroxy derivatives of commercially available petroselinic acid and 5-hydroxy-6-thioether derivatives of fatty acids containing an aromatic moiety were synthesized.Several of the compounds have exhibited SRS-A antagonist (eg, 5, 10)/agonist (eg, 34, 35) activity.Compound 5 antagonized SRS-A-induced contractions of the isolated guinea pig ileum with IC50 = 0.09 μM. hydroxythioether fatty acids / SRS-A / antagonist / agonist / peptidoleukotriene analogs
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(1993)
