Novel 6-5 fused ring heterocycle antifolates with potent antitumor activity: Bridge modifications and heterocyclic benzoyl isosters of 2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine antifolate

DOI: 10.1248/cpb.43.829

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 829 - 841 (1995)

Update date:2022-09-26

Topics:

Authors:

Kotake Kotake

Okauchi Okauchi

Iijima Iijima

Yoshimatsu

Nomura Nomura

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.43.829

Structural modifications of an extremely potent inhibitor of dihydrofolate reductase (DHFR) activity and tumor cell growth, N-[4-[3-(2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidin-5-yl)propyl ]benzoyl]-L-glutamic acid (1), have led to the synthesis of

Full text of DOI:10.1248/cpb.43.829

NII-Electronic Library Service

Products guided by the article

Product name:4-{1-[1-Ethoxycarbonyl-meth-(E)-ylidene]-propyl}-benzoic acid tert-butyl ester

Cas No:149325-55-3

R&D Labs maybe for 149325-55-3

Shaanxi HuaTai Bio-fine chemical company Ltd

Contact:86-029-87862197

Address:No. 5, 3rd Floor, 29 Yanta North Road, Beilin Dist.
Shanghai Profirst Co., Ltd.

Contact:+86-21-38122007

Address:2, Lane 1123, Kangqiao Road, Pudong New Area, Shanghai
Sichuan Mianzhu Ronghong Chemical Co.,LTd

Contact:8613981840544

Address:XINSHI INDUSTRY PARK,MIANZHU,SICHUAN,CHINA
Anhui Redstar Pharmaceutical Corp., Ltd

Contact:+86-563-5120837

Address:Jingxian Industrial Development Zone, Anhui , China
Synchemie Co., Ltd.

website:http://www.synchemie.com/

Contact:+86-574-87642758

Address:Room 901, Yinyi Bund Building， 132 Renmin Road

Relevant to this article

Reactivity of zinc dialkyldithiocarbamates towards halogen-substituted olefins

Doi:10.1002/recl.19931120502
(1993)
Ligand-enabled multiple absolute stereocontrol in metal-catalysed cycloaddition for construction of contiguous all-carbon quaternary stereocentres

Doi:10.1038/nchem.1796
(2014)
Catalytic synthesis of functional silicon-stereogenic silanes through Candida antarctica lipase B catalyzed remote desymmetrization of silicon-centered diols

Doi:10.1002/ejoc.201300932
(2013)
Biocatalytic dynamic kinetic reductive resolution with ketoreductase from: Klebsiella pneumoniae: The asymmetric synthesis of functionalized tetrahydropyrans

Doi:10.1039/c9ob01681c
(2019)
AgF-mediated fluorinative homocoupling of gem -difluoroalkenes

Doi:10.1021/ol403083e
(2014)
β-octamethoxyporphycenes

Doi:10.1021/ol403068j
(2014)

Article Doi