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Novel 6-5 fused ring heterocycle antifolates with potent antitumor activity: Bridge modifications and heterocyclic benzoyl isosters of 2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine antifolate

DOI: 10.1248/cpb.43.829

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 829 - 841 (1995)

Update date:2022-09-26

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Authors:

KotakeKotake

OkauchiOkauchi

IijimaIijima

YoshimatsuYoshimatsu

NomuraNomura

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Article abstract of DOI:10.1248/cpb.43.829

Structural modifications of an extremely potent inhibitor of dihydrofolate reductase (DHFR) activity and tumor cell growth, N-[4-[3-(2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidin-5-yl)propyl ]benzoyl]-L-glutamic acid (1), have led to the synthesis of

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Full text of DOI:10.1248/cpb.43.829

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Products guided by the article

Product name:4-{1-[1-Ethoxycarbonyl-meth-(E)-ylidene]-propyl}-benzoic acid tert-butyl ester

Cas No:149325-55-3

149325-55-3

R&D Labs maybe for 149325-55-3

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