A practical synthesis of 6-acetylsalicylic acid methyl ester

Article abstract of DOI:10.1080/00397919408010591

A new and efficient synthesis of the title compound is reported. The method includes a regioselective ortho-lithiation step in none polar solvents at an ambient temperature and the overall yield for 5 steps is more than 70% from a commercially available 3-hydroxyacetophenone.

Full text of DOI:10.1080/00397919408010591

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Synthetic Communications: An
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Organic Chemistry
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A Practical Synthesis of 6-
Acetylsalicylic Acid Methyl
Ester
Masatoshi Tamaru b , Kazuto Umezu a , Chika
Maejima a , Hiroyuki Kageyama a & Yoshikazu Kimura
a
a Research and Development Department , Ihara
Chemical Industry Co., Ltd , Fujikawa-cho, Ihara-
gun, Shizuoka, 421-33, Japan
b K-I Chemical Research Institute Co., Ltd , Fukude-
cho, Iwata-gun, Shizuoka, 437-12, Japan
Published online: 23 Sep 2006.
To cite this article: Masatoshi Tamaru , Kazuto Umezu , Chika Maejima , Hiroyuki
Kageyama & Yoshikazu Kimura (1994) A Practical Synthesis of 6-Acetylsalicylic
Acid Methyl Ester, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 24:19, 2749-2756, DOI:
10.1080/00397919408010591
To link to this article: http://dx.doi.org/10.1080/00397919408010591
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