Journal of Medicinal Chemistry p. 1616 - 1624 (1994)
Update date:2022-08-04
Topics: Synthesis Antitumor activities Antifolates
Kotake
Iijima
Yoshimatsu
Tamai
Ozawa
Koyanagi
Kitoh
Nomura
Novel antifolates with a 6-5 fused ring system, 6,7- dihydrocyclopenta[d]pyrimidine, (3a,b and 4a,b) were synthesized on the basis of combined modification of the heterocycle and bridge regions of the folate molecule. The synthetic method involves (1) syn
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