Inhibitors of Blood Platelet cAMP Phosphodiesterase. 4. Structural Variation of the Side-Chain Terminus of Water-Soluble 1,3-Dihydro-2H-imidazoquinolin-2-one Derivatives

DOI: 10.1021/jm00074a005

Source and publish data:

Journal of Medicinal Chemistry p. 3251 - 3264 (1993)

Update date:2022-08-04

Topics: Inhibitors Derivatives Water-soluble

Authors:

Meanwell, Nicholas A.

Hewawasam, Piyasena A.

Thomas, Jeanine

Wright, J. J. Kim

Russell, John W.

et al. et al.

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Article abstract of DOI:10.1021/jm00074a005

1-(Cyclohexylmethyl)-4-<4-<(2,3-dihydro-2-oxo-1H-imidazo<4,5-b>quinolin-7-yl)oxy>-1-oxobutyl>piperazine (2) was previously identified as a potent, water-soluble inhibitor of human blood platelet cAMP phosphodiesterase and of induced aggregation in vitro t

Full text of DOI:10.1021/jm00074a005

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