A Simple and Highly Diastereoselective Synthesis of A 1β-Methylcarbapenem Key Intermediate by Deallyloxycarbonylation Using Palladium Complexes

Article abstract of DOI:10.1016/0040-4039(94)85196-4

A simple, highly diastereoselective synthesis of the key 1β-methylcarbapenem intermediate 1 has been accomplished via a palladium catalyzed deallyloxycarbonylation of diallyl malonate derivative 4a which was readily prepared from (3S,4R)-4-acetoxy-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-2-azetidinone 2 in two steps.