A Simple and Highly Diastereoselective Synthesis of A 1β-Methylcarbapenem Key Intermediate by Deallyloxycarbonylation Using Palladium Complexes

DOI: 10.1016/0040-4039(94)85196-4

Source and publish data:

Tetrahedron Letters p. 2271 - 2274 (1994)

Update date:2022-08-04

Topics:

Authors:

Murayama, Toshiyuki

Yoshida, Akifumi

Kobayashi, Toyohiko

Miura, Takashi

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Article abstract of DOI:10.1016/0040-4039(94)85196-4

A simple, highly diastereoselective synthesis of the key 1β-methylcarbapenem intermediate 1 has been accomplished via a palladium catalyzed deallyloxycarbonylation of diallyl malonate derivative 4a which was readily prepared from (3S,4R)-4-acetoxy-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-2-azetidinone 2 in two steps.

Full text of DOI:10.1016/0040-4039(94)85196-4

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