β-(Trimethylsilyl)ethoxymethyl chloride. A new reagent for the protection of the hydroxyl group

DOI: 10.1016/S0040-4039(00)78684-9

Source and publish data:

Tetrahedron Letters p. 3343 - 3346 (1980)

Update date:2022-08-05

Topics: Chemical term Explanation Experimental term

Authors:

Lipshutz, Bruce H.

Pegram, Joseph J.

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Article abstract of DOI:10.1016/S0040-4039(00)78684-9

Reactions of β-(trimethylsilyl)ethoxymethyl chloride with alcohols afford the corresponding ethers in high yield. Deprotection using n-Bu₄NF in THF or HMPA cleanly regenerates the hydroxyl function.

Full text of DOI:10.1016/S0040-4039(00)78684-9

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