Chemical and Pharmaceutical Bulletin p. 1706 - 1718 (1995)
Update date:2022-08-04
Topics:
Miyazaki
Kobayashi
Natsume
Gondo
Mikami
Sakakibara
Tsukagoshi
Dolastatin 10 (1) is a potent antineoplastic pentapeptide. Novel dolastatin 10 analogs each modified at one of the constituent amino acid derivatives, were synthesized and their antitumor activity was evaluated against P388 leukemia in mice. The structural requirements for antitumor activity are discussed. Some of the analogs, 31c, 35c, 38b, and 50c showed excellent activity in vivo. Highly active 50c, which lacks the thiazole group of 1, was selected for further development as an antitumor agent.
View MoreContact:86-551-63540590
Address:No 1388 Furong Rd., Hefei, Anhui, China
Anhui Xinyuan Technology Co.,Ltd
Contact:0086-559-3515800
Address:No.16 Zijin Rd, Circular Economic Zone, Huizhou District, Huangshan Anhui China
PharmaResources(Kaiyuan)CO,.Ltd
Contact:+86-21-50720028
Address:No.3, Beihuan Road, Economic Development District, Kaiyuan City, Tieling City, Liaoning Province, China 112300
Suzhou BEC Fine Chemicals Co., Ltd.
website:http://www.bek.com.cn
Contact:0512-68095917 18913193865
Address:6, Jin Shan Road, Suzhou New District, 215011 China Suzhou Nations Pharmaceutical Innovation Center Inside
Hefei TNJ chemical industry co.,ltd
website:https://www.tnjchem.com
Contact:+86-551-65418695
Address:B911 Xincheng Business Center, Qianshan Road, Hefei Anhui China
Doi:10.1016/S0040-4020(01)81275-8
(1993)Doi:10.1002/hlca.19300130540
(1930)Doi:10.1007/BF00566988
()Doi:10.1021/jo01305a001
(1980)Doi:10.1021/jo01303a036
(1980)Doi:10.1016/j.carres.2007.12.020
(2008)
