Chemical and Pharmaceutical Bulletin p. 1706 - 1718 (1995)
Update date:2022-08-04
Topics:
Miyazaki
Kobayashi
Natsume
Gondo
Mikami
Sakakibara
Tsukagoshi
Dolastatin 10 (1) is a potent antineoplastic pentapeptide. Novel dolastatin 10 analogs each modified at one of the constituent amino acid derivatives, were synthesized and their antitumor activity was evaluated against P388 leukemia in mice. The structural requirements for antitumor activity are discussed. Some of the analogs, 31c, 35c, 38b, and 50c showed excellent activity in vivo. Highly active 50c, which lacks the thiazole group of 1, was selected for further development as an antitumor agent.
View MoreSuzhou Tianma Specialty Chemicals Co.,Ltd
Contact:+86-512-68090577
Address:#199, Huayuan Rd, Mudu, Suzhou, Jiangsu, CHINA
Contact:86-607-68073220
Address:1 ave na road jiahua st
suzhou chukai pharmateach co,.ltd
Contact:86-512-88812511
Address:Building 3, Wujiang Scientific Innovation Park, 2358 Changan Rd, Wujiang 215200, Jiangsu Province, P. R. China
Jiangsu King Road New Materials Co., Ltd.
website:http://www.jskingroad.com
Contact:0519-85720726 0519-85720721 13584535752
Address:No.1,Weihua Road,Xinbei District,Changzhou City,Jiangsu Province
Shanghai Yuanye Bio-Technology Co., Ltd.
website:http://www.shyuanye.com
Contact:+86-21-61845781
Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China
Doi:10.1016/S0040-4020(01)81275-8
(1993)Doi:10.1002/hlca.19300130540
(1930)Doi:10.1007/BF00566988
()Doi:10.1021/jo01305a001
(1980)Doi:10.1021/jo01303a036
(1980)Doi:10.1016/j.carres.2007.12.020
(2008)
