Green synthesis of dissymmetric bisarylidene derivatives of cyclohexanone analogues under ultrasonic conditions

Article abstract of DOI:10.1007/s13738-018-1498-5

Abstract: A new procedure is developed for the synthesis of dissymmetric bisarylidene derivatives of two cyclohexanone analogues. Under mild ultrasonic/organocatalytic conditions, the first aldehyde reacts with the ketone to give the monoarylidene intermediate which subsequently condenses with the second aldehyde upon addition of NaOH/MeOH to the reaction mixture. Both condensations proceed in one pot, and high yields of the corresponding products are obtained in relatively short time periods. It was shown that the method is useful for the synthesis of monoarylidene counterparts as well. Graphical abstract: [Figure not available: see fulltext.].