
Tetrahedron Letters p. 3593 - 3594 (1993)
Update date:2022-08-02
Topics:
Gomez-Monterrey, Isabel
Gonzalez-Muniz, Rosario
Herranz, Rosario
Garcia-Lopez, Teresa
Catalytic hydrogenation at 40 deg C of the β-ketoester, obtained from Boc-Orn(Z)-OH and ethyl lithioacetate, provides exclusively ethyl (2R,3S)-3-tert-butyloxycarbonylamino-2-piperidineacetic acid which when suitably protected can be used for peptide synthesis.
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Doi:10.1139/v93-153
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