Potent HIV Protease Inhibitors: The Development of Tetrahydrofuranylglycines as Novel P2 Ligands and Pyrazine Amides as P3-Ligands

DOI: 10.1021/jm00068a006

Source and publish data:

Journal of Medicinal Chemistry p. 2300 - 2310 (1993)

Update date:2022-09-26

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Authors:

Ghosh, Arun K.

Thompson, Wayne J.

Holloway, M. Katharine

McKee, Sean P.

Duong, Tien T.

et al. et al.

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Article abstract of DOI:10.1021/jm00068a006

A series of protease inhibitors bearing constrained unnaturel amino acids at the P₂-position and novel heterocycles at the P₃-position of compound 1 (Ro 31-8959) were synthesized, and their in vitro enzyme inhibitory and antiviral ac

Full text of DOI:10.1021/jm00068a006

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