
Tetrahedron p. 5305 - 5314 (1993)
Update date:2022-08-02
Topics:
Zarevucka, Marie
Rejzek, Martin
Wimmer, Zdenek
Saman, David
Streinz, Ludvik
For preparation of all four enantiomers of 2-(4-hydroxybenzyl)-1-cyclohexanol (1a-4a) by biotransformation reactions, Saccharomyces cerevisiae (SC) and pig pancreatic lipase (PPL) were used in aqueous media. The THP-protected substrates (5b, 6b and 7b) gave products with a good enantiomeric excess comparable with that of the CH3-protected substrates (5c, 6c and 7c), whereas the deprotection was much easier in case of the THP-protected compounds.
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Doi:10.1016/S0040-4020(01)82378-4
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